THE INHIBITORY EFFECTS OF ARTEMISININ-DERIVATIVES ON Na + AND K + CHANNELS IN COMPARISON WITH THOSE OF PROCAINE

( views:, downloads: )
Author:
HUANG FEN-SHENG()
HU Qian()
SHI Yu-liang()
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
Volume 50, Issue 02, 1998
DOI:
Key Word:

Abstract:

  • [1]Coordinating research group for the structure of artemisinin(青蒿素结构协作组).A new type of sesquiterpene lactone--artemisinin.Kexue Tongbao,1977,22:142(in Chinese).
  • [2]Coordinating research group for Qinghao(青蒿素结构协作组).Sttdies ofnew antimalarial artemisinin.Yaoxue Tongbao, 1979, 14:49 ~ 53 (in Chinese).
  • [3]Coordinating research group of Guangdong Hainan for Qinghaosu. Observation of antimalarial effect of Qinghaosu,65 cases. Xinyiyao Zazhi, 1979, 1: 12~ 16 (in Chinese).
  • [4]Daniel L, Klayman. Qinghaosu (Artemisinin): An antimalarial drug from China. Science, 1985, 228: 1049~1055.
  • [5]Li Y(李英),Wu SX(吴时祥),Jiang HJ(姜洪进).Synthesis of artemisinin derivatives containing nitrogen atom. ZL (China) 89109562. 4 (Cl C07D493/18. A61 K3135) 26, Feb, 1995, Appl 21, Dec. 1989.
  • [6]Enomoto KI, Higashida H, Maeno T. Effects of toki-shakuyaku-san (Tsumura TJ-23) on electrical activity in neuroblastoma × glioma cells and frog neuromuscular junctions. NeurosciRes, 1992, 15:81 ~89.
  • [7]Docherty BJ, Robbins J, Brown DA. NG108-15 neuroblastoma × glioma hybrid cell line as a model neuronal system. In: Chad J, Wheal H, ecs. Cdlular Neurobiology, A Practical Approach. Oxford: Oxford University Press, 1992, 75 ~ 95.
  • [8]Shi YL, Furuya S, Wang WP, et al. Toosendanin-induced Ca2+ conductance increase in neuroblastoma ×glioma hybrid cells. Chin SciBull, 1993, 38: 1489~ 1493.
  • [9]Hu Q, Huang FS, Shi YL. Inhibition of toosendanin on the delayed rectifier potassium current in neuroblastoma × glioma cells. Brain Res, 1997, 751:47 ~ 53.
  • [10]HuQ(胡谦),ShiYL(施玉樑).Ion channels at neuroblastoma×glioma NG108-15 cell and its application in analyzing the actions of bioaetive substances. Chin J Neurosci, 1997, 4: 188~ 193(in Chinese with English abstract).
  • [11]Huang FS(黄汾生),Hu Q(胡谦),Shi YL(施玉樑)et al.A comparison of the inhibitory effects of artemisinin-derivatives and procaine on Na + , K * channels. 6th Chinese National Symposium on Biomembrane.1996, p154 (abstract in Chinese).
  • [12]Shi YL(施玉樑),Xu YF(徐幼芬),Gu C(顾琛),et al.Reversible elimination of K+and Na+ currents at motor nerve terminals by SM486, a derivative of artermisinin. Acta Physiol Sin, 1995, 47: 25~ 30 (in Chinese with English abstract).
  • [13]Furuya K, Furuya S, Yamagishi S. Developmental time courses of Na and Ca spikes in neuroblastoma× glioma hybrid cells. Dev el Brain Res, 1983, 11: 229~ 234.
  • [14]Hu Q, Shi YL. Characterization of an inward-rectifying potassium current in NG108-15 neuroblastoma × glioma cells. Pfluger' s Arch Eur J Physiol, 1997, 433: 617~625.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn