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VOLTAGE DEPENDENCE OF LATE Na CHANNEL WITH BURST MODE IN ISOLATED CARDIAC MYOCYTES
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.1997.05.002
- Key Word:
- 游离心室肌细胞;膜片箝;晚钠电流;模式;爆发型
Abstract： 应用膜片箝技术记录豚鼠游离心室肌细胞钠通道电流,发现除极可引起晚钠电流爆发型开放,而复极可终止爆发型活动.爆发型模式的通道电流不仅有浓度依赖性和电位依赖性,其开放时间常数也随箝制电位变正而增大.多步阶梯式除极和斜线除极的实验结果首次表明电位变化愈迅速、除极步数愈多,爆发型出现的机率也就愈高.
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