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NOREPHINEPHRINE REGULATION OF T-LYMPHOCYTE PROLIFERATION OF RAT DURING ACUTE HYPOXIA
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0371-0874.1997.03.004
- Key Word:
- 低氧;淋巴细胞转化;NE免疫调节;CRF
Abstract： 本研究以模拟高原低氧方法,观察低氧作用于大鼠细胞免疫功能以及去甲肾上腺素(NE)对免疫作用的调节机制.实验结果:与对照相比,7 km急性低氧24 h淋巴细胞转化下降41%(P＜0.01);5 km低氧暴露时间为7 d,20 d时,低氧抑制淋巴细胞转化,分别下降34%和60%(P＜0.01);侧脑室注入5 nmol/L NE,淋巴细胞转化比对照下降29%(P＜0.01);7 km 10 h低氧暴露时,侧脑室注入酚妥拉明(phentolamin)25μg/rat则使低氧抑制淋巴细胞转化从42%提高到21%(P＜0.05);侧脑室注入5 nmol/L NE,血液CRF水平升高,脑室注入酚妥拉明后则降低;7 km 24 h低氧,下丘脑儿茶酚胺水平升高,血液CRF水平也升高;7 km 10 h低氧暴露的脾淋巴细胞加入不同浓度的CRF体外培养,呈现出浓度依赖性淋巴细胞转化下降现象.因而,本研究提示:低氧可抑制淋巴细胞转化,NE参与急性低氧下对大鼠细胞免疫功能的神经内分泌调节,其调节作用可能与CRF有关系.
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