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EFFECTS OF ENDOTHELIN ON ELECTROPHYSIOLOGICAL AND CONTRACTILE ACTIVITY OF GUINEA PIG PAPILLARY MUSCLES

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Author:
No author available
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
2
DOI:
10.3321/j.issn:0371-0874.1997.02.005
Key Word:
内皮素;TEA;BQ-123;硝苯吡啶;APⅢ;乳头肌;电生理

Abstract: 应用细胞内微电极和肌张力记录技术,观察了ET-1对豚鼠乳头肌细胞电生理和机械收缩活动的影响.结果表明:ET-1浓度依赖地明显延长PPD和APD90,增加心肌收缩张力;钾通道阻断剂TEA不影响ET-1的生物效应;而L型钙通道阻断剂硝苯吡啶、ETA受体选择性拮抗剂BQ-123和APⅢ以浓度依赖的方式阻断ET-1的上述效应,提示ET-1对乳头肌的电生理和正性肌力效应是由ETA受体亚型介导的,与胞浆内Ca2+升高有关.

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