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A MICRODIALYSIS STUDY OF EXCITATORY AMINO ACID LEVELS OF THE MONKEYS' CAUDATE NUCLEUS DURING THE DELAYED GO/NO-GO TASK
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0371-0874.1997.02.002
- Key Word:
- 尾核;延缓go/no-go任务;兴奋性氨基酸;脑内微透析;猕猴
Abstract： 本研究将脑内在体(in vivo)微透析采样技术和高效液相色谱-荧光检测分析法相结合,监测了猕猴(Macaca mulatta)在履行一种延缓go/no-go任务中其尾核内的兴奋性氨基酸水平的变化.在这种行为任务操作中,猴必须根据记忆中保持的暗示信号的位置来发动(go)或抑制(no-go)随后的运动反应,因此具有短时工作记忆性质.我们发现,在这种行为任务操作过程中,猴尾核透析液中的Glu和Asp水平较操作前基础水平分别降低(31.68±3.85)%(n=10)和(26.25±5.95)%(n=10),具有极显著的统计意义(Glu:t9=6.51,P＜0.001;Asp:t9=3.39,P＜0.01).同时,透析液中的Gln和Asn水平也显著降低(P＜0.05).相反,在没有延缓期的go/no-go任务和单纯的延缓go任务操作过程中,尾核透析液中Glu,Asp,Gln和Asn的水平均无显著性变化.这一结果提示,尾核内的兴奋性氨基酸递质传递参与延缓go/no-go任务的操作过程,为尾核内谷氨酸能传递参与运动工作记忆调控提供了直接的实验证据.
- [1]G E, Alexander,M R, DeLong,P L, Strick.Parallel organization of functionally segregated circuits linking basal ganglia and cortex.[J].1986,9.
- [2]G V, Williams,P S, Goldman-Rakic.Modulation of memory fields by dopamine D1 receptors in prefrontal cortex.[J].1995,376(6541).
- [3]J. Kornhuber,M.E. Kornhuber.Presynaptic dopaminergic modulation of cortical input to the striatum[J].1986,39(8).
- [4]T Aosaki,AM Graybiel,M Kimura.Effect of the nigrostriatal dopamine system on acquired neural responses in the striatum of behaving monkeys[J].1994,265 (5170).
- [5]P J, Eslinger,L M, Grattan.Frontal lobe and frontal-striatal substrates for different forms of human cognitive flexibility.[J].1993,31(1).
- [6]尹萍波,李葆明,梅镇彤.延缓GO/NO-GO行为作业相关的猴尾核神经元电活动[J].1996,(2).
- [7]G, Di Chiara,M, Morelli,S, Consolo.Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions.[J].1994,17(6).
- [8]Middleton, Frank A.,Strick, Peter L..Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function.[J].1994,266(5184).
- [9]S, Funahashi,K, Kubota.Working memory and prefrontal cortex.[J].1994,21(1).
- [10]M.W. Warenycia,G.M. McKenzie,M. Murphy,etc.The effects of cortical ablation on multiple unit activity in the striatum following dexamphetamine[J].1987,26(8).
- [11]Bryan K. Yamamoto,Sheri Davy.Dopaminergic Modulation of Glutamate Release in Striatum as Measured by Microdialysis[J].1992,58(5).
- [12]尹萍波,梅镇彤.脑内微透析采样技术及其在神经科学中的应用[J].1995,(3).
- [13]Jason Brandt,Nelson Butters.The neuropsychology of Huntington's disease[J].1986,9(1).
- [14]叶惟泠,尹萍波.高效液相色谱法测定动物脑和脊髓内微透析样品中的递质氨基酸和单胺类递质及其代谢产物[J].1996,(1).