You Position: Home > Paper
SOMATOSTATIN INHIBITED PAIN MODULATION ACTION OF SUBSTANCE P IN SPINAL CORD
( views:21, downloads:0 )
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0371-0874.1997.01.003
- Key Word:
- P物质;生长抑素;原癌基因c-fos;Fos蛋白;脊髓;免疫组化
Abstract： 本研究应用痛阈测定及免疫组化法,探讨生长抑素(SST)对脊髓P物质(SP)痛觉调制作用的影响.结果表明,鞘内注射(it)SST(10μg)可使痛阈提高,并可抑制SP引起的痛反应及脊髓c-fos表达;大鼠足底注射福尔马林(For)不仅引起痛反应,还可使脊髓SP样免疫反应物(SP-LI)增加,而it SST可抑制For引起的痛反应及脊髓SP-LI增多效应.说明SST可通过抑制SP及其引起的伤害性反应而产生镇痛作用.
- [1]阮怀珍,李希成,蔡文琴,等.Participation of Substance P in Noxious Stimulus-Evoked C-Fos Expression in Spinal Cord[J].1994,(20).
- [2]V. Chapman,A.H. Dickenson.The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord[J].1992,23(3).
- [3]朱丽霞,黎春元,吉长福.P物质在脊髓水平痛觉传递与痛觉调制中的双重作用[J].1986,(12).
- [4]D, Dubuisson,S G, Dennis.The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats.[J].1977,4(2).
- [5]Mirjana Randić,Vjekoslav Miletić.Depressant actions of methionine-enkephalin and somatostatin in cat dorsal horn neurones activated by noxious stimuli[J].1978,152(1).
- [6]D M, Gaumann,T L, Yaksh,C, Post,etc.Intrathecal somatostatin in cat and mouse studies on pain, motor behavior, and histopathology.[J].1989,68.
- [7]张淼,纪如荣,方园,等.局部辣椒素处理抑制福尔马林诱导的脊髓FOS表达（英文）[J].1994,(1).
- [8]J, Meynadier,J, Chrubasik,M, Dubar,etc.Intrathecal somatostatin in terminally ill patients. A report of two cases.[J].1985,23.
- [9]Yasushi Kuraishi,Naoyoshi Hirota,Yoichi Sato,etc.Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn[J].1985,325(1-2).
- [10]阮怀珍,李希成.Effects of Morphine and Monoamine Neurotransmitters on Pain Modulation of Substance P in the Spinal Cord[J].1991,(8).
- [11]E, Bullitt.Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat.[J].1990,296(4).
- [12]H. Matsumura,T. Sakurada,A. Hara,etc.Characterization of the hyperalgesic effect induced by intrathecal injection of substance P[J].1985,24(5).
- [13]李希成,黎海蒂.脑室注射生长抑素对大鼠痛阈和脑内单胺类，黄嘌...[J].1991,012 (6).
- [14]J, Chrubasik,J, Meynadier,P, Scherpereel,etc.The effect of epidural somatostatin on postoperative pain.[J].1985,64.
- [15]P, Mollenholt,C, Post,N, Rawal,etc.Antinociceptive and 'neurotoxic' actions of somatostatin in rat spinal cord after intrathecal administration.[J].1988,32.
- [16]阮怀珍,李希成,黎海蒂.Effects of Morphine and Electroacupuncture on Substance P Level in Spinal Cord and Their Relation to Pain Threshold in Rats[J].1993,(1).
- [17]T L, Yaksh,T A, Rudy.Chronic catheterization of the spinal subarachnoid space.[J].1976,17(6).