Novel therapy for idiopathic pulmonary arterial hypertension: Can hepatocyte growth factor be beneficial?

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Author:
Ying-Hua Guo(Nanlou Respiratory Disease Department, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)
Long-Xiang Su(Nanlou Respiratory Disease Department, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China;Medical School, Nankai University, Tianjin 300071, China)
Na Guo(Nanlou Respiratory Disease Department, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)
Chang-Ting Liu(Nanlou Respiratory Disease Department, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)
Journal Title:
JOURNAL OF GERIATRIC CARDIOLOGY
Issue:
Volume 09, Issue 02, 2012
DOI:
10.3724/SP.J.1263.2012.02131
Key Word:
Idiopathic pulmonary arterial hypertension;Hepatocyte growth factor;Treatment;Mechanism

Abstract´╝Ü

  • [1]Guo YH,He JG,Wu JL,et al.Hepatocyte growth factor and granulocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy.Cytotherapy 2008;10:857-867.
  • [2]Katsha AM,Ohkouchi S,Xin H,et al.Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastaseinduced emphysema model.Mol Ther 2011;19:196-203.
  • [3]Ono M,Sawa Y,Mizuno S,et al.Hepatocyte growth factor suppresses vascular medial hyperplasia and matrix accumulation in advanced pulmonary hypertension of rats.Circulation 2004;110:2896-2902.
  • [4]Cartwright JE,Tse WK,Whitley GS.Hepatocyte growth factor induced human trophoblast motility involves phosphatidylinositol-3-kinase,mitogen-activated protein kinase,and inducible nitric oxide synthase.Exp Cell Res 2002;279:219-226.
  • [5]Yang ZJ,Xu SL,Chen B,et al.Hepatocyte growth factor plays a critical role in the regulation of cytokine production and induction of endothelial progenitor cell mobilization:a pilot gene therapy study in patients with coronary heart disease.Clin Exp Pharmacol Physiol 2009;36:790-796.
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