Relationships between vascular factors and plaque morphology in patients with acute coronary syndrome

( views:, downloads: )
Weiqiang Kang(Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266011, China)
Dalin Song(Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266011, China)
Guoren Ren(Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266011, China)
Jilong Teng(Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266011, China)
Journal Title:
Volume 6, Issue 02, 2009
Key Word:
Acute coronary syndrome;cytometrie bead array;vascular factors;intravaseular ultrasound

Abstract: Objective To investigate the relationships between vascular factors and plaque morphology in the patients with acute coronary syndrome(ACS). Methods lntravascular ultrasound(IVUS) was performed on 56 consecutively enrolled patients with ACS. Cytometric bead array for seven vascular factors(sPE,t-PA, MCP-I, IL-8,IL-6,sVCAM-1, and sCD40L) was measured by cytometry. The others biomarkers were tested by ELISA or biochemistry. Differences in bio-factors were compared between vulnerable plaque and non- vulnerable plaque groups, accte myocardial infarction (AMI) and ustable angina (UA) patients, and occurring plaque rupture. The relationship between the parameters of morphology and vascular factors was analyzed. Results There were positive correlations between sVCAM-1sPE, sVCAM-1-sCD40L, sCD40L-sPE, IL-6-IL8,IL8-MCP4, and MCPI-sVCAM-1; CRP (18.868±4.907mg/L vs 5.806±3.553 mg/L)and IL-6 (19.5 pg/ml [9.2±44.6 pg/ml]vs 5.3 pg/ml [2.3~ 13.4 pg/ml])were elevated in the vulnerable plaque group(P <0.05). sCD40L(473.82±126.11 vs 237.94±34.78 pg/mi),sPE (107.214±39.90 vs 49.06±5.61 μg/L) and MCP-1(132.42±17.85 vs 127.174±13.27 pg/ml) were increased in the plaque rupture group(P < 0.05);There was correlation between tPA and plaque morphology(P < 0.05). Increases in sCD40L, MCP-1, sPE, and TC were independent factors for plaque rupture. Conclusions IL-6 and CRP may be biomarkers for vulnerable plaque and for diagnosis ofAMI, sCD40L, MCP-1 and sPE are potential markers when for plaque rupture patient present with severe ACS.

  • [1]Braunwald E.Unstable angina:an etiologic approach to management.Circulation 1998,98:2219-22.
  • [2]Mintz GS,Nissen SE,Anderson WD,et al.American College of Cardiology clinical expert consensus document on standards for acquisition,measurement and reporting of intravascular ultrasound studies (IVUS):a report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents.J Am Coil Cardiol 2001; 37:1478-92.
  • [3]Armstrong EJ,Morrow DA,Sabatine MS.Inflammatory biomarkers in acute coronary syndromes partl:introduction and cytokine.Circulation 2006; 113:e72-5.
  • [4]Lindmark E,Diderholm E,Wallentin L,et al.Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease:effects of an early invasive or noninvasive strategy.JAMA 2001; 286:2154-6.
  • [5]Blankenberg S,Rupprocht H,Bickel C,et al.Circulating cell adhesion molecules and death in patients with coronary artery disease.Circulation 2001 ; 104:1336-42.
  • [6]Ivandic BT,Spanuth E,Haase D,et al.Increased plasma concentrations of soluble CD40 ligand in acute coronary syndrome depend on in vitro platelet activation.Clin Chem 2007; 53:1231 -4.
  • [7]de Lemos J,Morrow D,Sabatine M,et al.Association between plasma levels of monocyte chemoattractant protein-1 and longterm clinical outcomes in patients with acute coronary syndromes.Circulation 2003; 107:690-5.
  • [8]Burke AP,Farb A,Malcom GT,et al.Plaque rupture and sudden death related to exertion in men with coronary artery disease.JAMA 1999; 281:921-6.
  • [9]McCarthy MJ,Loftus IM,Thompson MM,et al.Angiogenesis and the atherosclerotic carotid plaque:an association between symptomatology and plaque morphology.J Vase Surg 1999; 30:261-8.
  • [10]Jeziorska M,Woolley DE.Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries.J Pathol 1999; 188:189-96.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615