The effection of Shenfu Injection (Ginseng-radix aconitum Injection) to the coagulation in the patient of multiple trauma complicated with shock

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JIANG Guo-ping(The Emergency Center of The Second Affiliated Hospital, College of Medicine,Zhejiang University, Hangzhou310009, China)
LEI Li-mei()
WEN Huai(The Emergency Center of The Second Affiliated Hospital, College of Medicine,Zhejiang University, Hangzhou310009 , China)
LOU Tian-zheng()
XU Wei-hai()
Journal Title:
Chinese Journal of Emergency Medicine
Volume 21, Issue 10, 2012
Key Word:
Shenfu Injection; Multiple injuries ; Shock ; Coagulation system; Acute traumatic coagulopathy; Mechanism ; Hemostatic resuscitation

Abstract: Objective To investigate the effection of Shenfu Injection (Ginseng-radix aconitum Injection)to the blood coagulation system and its prognosis in the patient of multiple trauma complicated with shock.Methods We prospectively studied 90 patients of multiple trauma complicated with shock,who came from the emergency center of the Second Affiliated Hospital of Medicine' s college of Zhe-Jiang University and emergency department of Lishui People' s Hospital from February 2007 to December 2011,and excluded those suffered with the dysfunction of coagulation system and uncontrolled ongoing bleeding before trauma.And then these eligible patients were randomly divided into two groups:treatment group ( 45 cases ) and control group (45 cases),the control group were received the routine treatment,the treatment group were received Shenfu Injection in early stage based on the routine treatment.The two groups were measured the platelet count (PLT),prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT),fibrinogen (FIB) before treatment and 3,7 days after treatment.Results The differences of the PLT,PT,APTT,TT,FIB between the treatment group and control group at 3,7 d after the treatment was statistically significant (P < 0.05 ). Conclusions Shenfu Injection has positive regulation to the coagulation system in the patient of multiple trauma complicated with shock.

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