The effection of Shenfu Injection (Ginseng-radix aconitum Injection) to the coagulation in the patient of multiple trauma complicated with shock

( views:290, downloads:0 )
Author:
JIANG Guo-ping(The Emergency Center of The Second Affiliated Hospital, College of Medicine,Zhejiang University, Hangzhou310009, China)
LEI Li-mei()
WEN Huai(The Emergency Center of The Second Affiliated Hospital, College of Medicine,Zhejiang University, Hangzhou310009 , China)
LOU Tian-zheng()
XU Wei-hai()
Journal Title:
Chinese Journal of Emergency Medicine
Issue:
Volume 21, Issue 10, 2012
DOI:
10.3760/cma.j.issn.1671-0282.2012.10.015
Key Word:
Shenfu Injection; Multiple injuries ; Shock ; Coagulation system; Acute traumatic coagulopathy; Mechanism ; Hemostatic resuscitation

Abstract: Objective To investigate the effection of Shenfu Injection (Ginseng-radix aconitum Injection)to the blood coagulation system and its prognosis in the patient of multiple trauma complicated with shock.Methods We prospectively studied 90 patients of multiple trauma complicated with shock,who came from the emergency center of the Second Affiliated Hospital of Medicine' s college of Zhe-Jiang University and emergency department of Lishui People' s Hospital from February 2007 to December 2011,and excluded those suffered with the dysfunction of coagulation system and uncontrolled ongoing bleeding before trauma.And then these eligible patients were randomly divided into two groups:treatment group ( 45 cases ) and control group (45 cases),the control group were received the routine treatment,the treatment group were received Shenfu Injection in early stage based on the routine treatment.The two groups were measured the platelet count (PLT),prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT),fibrinogen (FIB) before treatment and 3,7 days after treatment.Results The differences of the PLT,PT,APTT,TT,FIB between the treatment group and control group at 3,7 d after the treatment was statistically significant (P < 0.05 ). Conclusions Shenfu Injection has positive regulation to the coagulation system in the patient of multiple trauma complicated with shock.

  • [1]Frith D,Davenport R,Brohi K. Acute traumatic coagulopathy[J].Curr Opin Anaesthesiol,2012,25 (2):229-34.
  • [2]王正国.创伤研究进展[J].中华急诊医学杂志,2012,21(6):565-567.
  • [3]Marius K.Pathophysiology of polytrauma injury[J].Int J Care Injured,2005,36 (6):691-709.
  • [4]Floccard B,Rugeri L,Faure A,et al. Early coagulopathy in trauma patients:an on-scene and hospital admission study[J].Injury,2012,43 (1):26-32.
  • [5]Brohi K,Singh J,Heron M,et al.Acute traumatic coagulopathy[J].J Trauma,2003,54 (6):1127-1130.
  • [6]Maegele M,Lefering R,Yucel N,et al.Early coagulopathy in multiple injury:an analysis from the German Trauma Registry on 8724 patients[J].Injury,2007,38 (3):298-304.
  • [7]Rugeri L,Levrat A,David JS,et al.Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography[J].J Thromb Haemost,2007,5 (2):289-295.
  • [8]Plotkin AJ,Wade CE,Jenkins DH,et al.A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries[J].J Trauma,2008,64 (2 Suppl):S64-68.
  • [9]Zhang MY,Ji XF,Wang S,et al.Shen-Fu injection attenuates postresuscitation lung injury in a porcine model of cardiac arrest[J].Resuscitation,2012,83 (9):1152-1158.
  • [10]Hong F,He C,Liu X,et al.Protective effect of Shenfu injection on thromboangiitis obliterans model rats[J].J Ethnopharmacol,2011,138 (2):458-462.
  • [11]Wu Y,Xia ZY,Meng QT,et al.Shen-Fu injection preconditioning inhibits myocardial ischemia-reperfusion injury in diabetic rats:activation of eNOS via the PI3K/Akt pathway[J].J Biomed Biotechnol,2011,384627:1-9.
  • [12]Ji XF,Yang L,Zhang MY,et al.Shen-fu injection attenuates postresuscitation myocardial dysfunction in a porcine model of cardiac arrest[J].Shock,2011,35 (5):530-536.
  • [13]Zhang T,Zhao M.Protective effect of SHEN-FU injection on heart injury induced by ischemia/reperfusion[J].J Mol & Cel Card,2007,42 (6):S209-S210.
  • [14]Schochl H, Maegele M, Solomon C, et al. Early and individualized goal-directed therapy for trauma-induced coagulopathy[J].Scand J Trauma Resusc Emerg Med,2012,20:15.
  • [15]Johansson PI,Stissing T,Bochsen L,et al.Thrombelastography and tromboelastometry in assessing coagulopathy in trauma[J].Scand J Trauma Resusc Emerg Med,2009,17:45.
  • [16]Wafaisade A,Wutzler S,Lefering R,et al. Drivers of acute coagulopathy after severe trauma:a multivariate analysis of 1987patients[J].Emerg Med J,2010,27 (12):934-939.
  • [17]Harr JN,Moore EE,Wohlauer MV,et al. Association for academic surgery the acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength[J].J Surg R,2011,170:319-324.
  • [18]杨帆,白祥军,刘开俊,等.严重多发伤并发症的早期控制[J].中华急诊医学杂志,2009,18 (6):628-631.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn