You Position: Home > Paper

Effects of anisodamine on neurological functional status of cerebral resuscitation: a systematic review and meta-analysis

( views:433, downloads:112 )
Author:
No author available
Journal Title:
Chinese Journal of Emergency Medicine
Issue:
1
DOI:
10.3760/cma.j.issn.1671-0282.2012.01.007
Key Word:
山莨菪碱;脑复苏;神经功能;系统评价;Meta分析;Anisodamine;Cerebral resuscitation;Neurological function;Systematic review;Meta-analysis

Abstract: Objective To evaluate the clinical effects of Anisodamine on neurological function as well as the safety of using it after cerebral resuscitation. Methods The data of CNKI (from January 1979 through January 2011 ) and Pubmed (from January 1978 through January 2011 ) were searched.The Cochrane Library was applied for identifying randomized controlled trials (RCTs) about effects of Anisodamine on neurological function after cerebral resuscitation.The methodological quality was assessed and the data were collected according to the criteria defined in Cochrane Reviewer' s Handbook for meta-analyses with RevMan 5.0.25 package.Results Data of 327 patients from 4 eligible studies were included in this analysis.The results of meta-analyses showed that Anisodamine used after cerebral resuscitation improved Glasgow coma scale (GCS) in the early stage [ MD =1.4,95% CI (0.98,1.82),P <0.01 ] and lessen neurological deficit (ND) in the later stage [ MD =-4.38,95%CI ( -5.26, -3.51 ),P <0.01 ].Meanwhile,the reduction of long-term ND of patients was documented in two studies ; the improvement of ability of daily life of patients in 2 ~ 3 months after anisodamine used was reported in two studies; the improvement of patients' quality of life (QL) was recorded in one study and the inhibited release of excitatory amino acid (EAA) was reported in one study.All eligible studies did not report any serious adverse effects of Anisodamine used after cerebral resuscitation. Conclusions Anisodamine used after cerebral resuscitation can improve patients'status of neurological function with relative safety of administration.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn