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Comparison of the effectiveness of intravenous diltiazem and metoprolol in controlling the rapid ventricular rate in patients with atrial fibrillation

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF EMERGENCY MEDICINE
Issue:
10
DOI:
10.3760/cma.j.issn.1671-0282.2009.10.022
Key Word:
心房颤动;地尔硫卓;美托洛尔;静脉注射;疗效;Atrial fibrillation;Diltiazem;Metoprolol;Intravenous;Effectiveness

Abstract: Objective To compare the effectiveness between dilfiazem and metoprolol administered intra-venously on controlling the ventricular tachy-cardia in patients with atrial fibrillation (AF). Method From Jan-uaxy 2003 to July 2006, 48 AF patients in the Second Hospital, Jilin University, with a ventricular rate > 120 beats per minute and systolic blood pressure > 100 mmHg were enrolled and divided into dihiazem group (10 mg, Ⅳ, n = 24) or metoprolol group (5 mg, Ⅳ, n = 24). Blood pressure and heart rote were re-checked at different inter-vals of 5, 10, 15 and 30 minutes,respectively. Successful treatment was defined as ventricular rate < 100 beat/ min or decrease > 20% of the pre-treatment level, or restoumtion of sinus rhythm. Results Compared with pre-treatment value, a significant deceleration in ventricular response to AF was observed after treatment in both groups at each interval (P < 0.01). However, the ventricular rate in the diltiazem group was significantly lower than that in the metoprolol group (P <0.05) at all intervals but 30 minutes. A slight decrease in blood pressure was ob-served in both groups. The drop of blood pressure between two groups was comparable. The successful treatment at the interval of 30 minutes was achieved in 91.7% of patients in dihiazem group and 83.3% of patients in metopro-lol group (P < 0.05). Conclusions Both diltiazem (10 mg, Ⅳ) and metoproiol (5 mg, Ⅳ) are effective on con-trolling the accelerated ventricular response to AF, in particular, the effect of diltiazem seems much superior to ahat of metoprolol.

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