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Change and role of kidney interstitial dendritic cells in mice with multiple organ dysfunction syndrome
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 11
- DOI:
- 10.3760/j.issn:1671-0282.2007.11.008
- Key Word:
- 多器官功能障碍综合征;树突状细胞;电子显微镜;CD205;I-Ab
Abstract： 目的 探讨肾脏间质树突状细胞在多器官功能障碍综合征免疫紊乱中的影响与作用.方法 腹腔注射酵母多糖制造C57BL/6小鼠MODS模型,分为正常、3～6 h、12～48 h、5～7 d和10～12 d组.观察各组小鼠肾脏间质树突状细胞的病理学变化及其表面标记物CD11c、CD205、CD80和I-Ab在MODS各期肾脏中的表达水平;流式细胞术检测外周血CD4+与CD8+的T细胞数量与比值.结果 在急性损伤期,肾脏间质树突状细胞大量增生,CD 80和I-Ab表达较正常组差异具有统计学意义(P《0.01和P《0.05),外周血T细胞CD4+/CD8+比值则明显下降(P《0.01).功能衰竭期,肾脏间质树突状细胞增生至最高点,但其CD80和I-Ab表达较急性损伤期显著减少(P《0.01),外周血T细胞CD4+/CD8+比值下降至最低(P《0.01).结论 肾脏间质树突状细胞参与并影响了MODS中肾脏局部与全身的免疫失衡及免疫抑制过程.
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