Guided Haversian remodeling in acute bone trauma in rabbit ribia and mandible
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 8
- DOI:
- 10.3760/j.issn:1671-0282.2007.08.001
- Key Word:
- 哈弗氏系统;骨损伤;海藻酸钙膜;引导组织再生;骨诱导因子;Haversian canal;Bone trauma;Calcium alginate film;Guided tissue regeneration;Osteoinductive factors
Abstract： Objective To search a better novae biomaterial applied to guide bone regeneration for promoting the healing of acute bone trauma by the experimental study of Haversian remodeling.Method Circular bone defects of 5mm diameter were created in tibias and the corners of mandibles in 36 rabbits.The defects were covered with calcium alginate film (CAF) in the experimental group, collagen membrane (CM)and no membrane (blank) in the control groups respectively. Healing conditions were analyzed using gross inspection, and histological and immunohistochemical studies after 1, 2, 4, 6 and 8 weeks respectively.Results The experimental group appeared more and earlier Haversian remodeling with osteoinductive factors leading to better bone regeneration. The control groups showed more macrophages with CM absorbed slowly, weak and delayed Haversian remodeling, and less osteoinductive factors ( P ＜ 0.05) in the early stage.Conclusions Calcium alginate film, as a relatively cheaper biomaterial, provided better effect than the collagen membrane on guided bone regeneration, because of its better Haversian remodeling and more content of osteoinductive factors shown in this experiment.
- [1]顾耕华,何虹,黄剑奇,等.海藻酸钙膜促进胫骨损伤修复机制的实验研究[J].2002,(6).
- [2]Jardini MA,De Marco AC,Lima LA.Early healing pattern of autogenous bone grafts with and without e-PTFE membranes: a histomorphometric study in rats.[J].2005,100(6).
- [3]Donos N,Kostopoulos L,Tonetti M,etc.Long-term stability of autogenous bone grafts following combined application with guided bone regeneration.[J].2005,16(2).
- [4]Lioubavina Hack N,Lindhe J,Lynch SE,etc.Methyl cellulose gel obstructed bone formation by GBR: an experimental study in rats.[J].2005,32(12).
- [5]L F, Bonewald,G R, Mundy.Role of transforming growth factor-beta in bone remodeling.[J].1990.
- [6]Baba H.,Maezawa Y.,Fukuda M.,etc.Expression of various growth factors for cell proliferation and cytodifferentiation during fracture repair of bone[J].2000,44(3).
- [7]Kotaki M,Ramakrishna S,Fujihara K.Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers[J].2005,26(19).
- [8]Taguchi Y,Amizuka N,Nakadate M,etc.A histological evaluation for guided bone regeneration induced by a collagenous membrane[J].2005,26(31).
- [9]S D, Boden,G A, Hair,M, Viggeswarapu,etc.Gene therapy for spine fusion.[J].2000,(379 Suppl).
- [10]Ishikawa K,Suzuki K,Koyama T,etc.Self-setting barrier membrane for guided tissue regeneration method: initial evaluation of alginate membrane made with sodium alginate and calcium chloride aqueous solutions.[J].1999,47(2).
- [11]Genghua G,Jianqi H,Lieping S,etc.Comparison of calcium alginate film with collagen membrane for guided bone regeneration in mandibular defects in rabbits.[J].2002,60(12).
- [12]R, Kenley,L, Marden,T, Turek,etc.Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2).[J].1994,28(10).
- [13]Franceschi RT.Biological approaches to bone regeneration by gene therapy.[J].2005,84(12).
- [14]Dimitriou R,Tsiridis E,Giannoudis PV.Current concepts of molecular aspects of bone healing.[J].2005,36(12).
- [15]A H, Reddi.Initiation of fracture repair by bone morphogenetic proteins.[J].1998,(355 Suppl).