You Position: Home > Paper
Relationship between high-sensitive C-reactive protein,adiponectin and the severity of patients with acute traumatic brain injury
( views:196, downloads:72 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1671-0282.2007.06.005
- Key Word:
- 颅脑损伤;高敏C-反应蛋白;脂联素
Abstract： 目的 检测急性颅脑损伤后患者外周血高敏C-反应蛋白(Hs-CRP)和脂联素水平的动态变化,探讨其临床意义.方法 选择101例不同病情的急性颅脑损伤患者作为研究对象,32例健康体检者作为对照组.采用免疫浊度法检测血清Hs-CRP,ELISA法检测脂联素水平.结果 急性颅脑损伤患者血清Hs-CRP水平均显著高于正常人对照组(P＜0.01),且患者Hs-CRP水平与病情呈正相关;急性颅脑损伤患者血清脂联素含量明显低于正常对照组(P＜0.01),与病情呈负相关;各组患者在入院当天Hs-CRP水平有所升高,并在人院后继续升高,Hs-CRP在1 d达高峰,随即开始下降;脂联素含量在人院当天有所降低,于3 d达最低水平,以后逐渐上升;患者脂联素水平与Hs-CRP呈负相关(r=-0.53,P＜0.01).结论 急性颅脑损伤患者外周血脂联素和Hs-CRP水平的变化与病情严重程度密切相关.
- [1]李巧玉,袁志诚,陆军,等.颅脑损伤后血清C-反应蛋白动态变化及临床意义[J].2000,(11).
- [2]Winter CD,Clough GF,Pringle AK,etc.Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury.[J].2004,127(Pt.2).
- [3]Morganti-Kossmann MC,Rancan M,Kossmann T,etc.Role of cerebral inflammation after traumatic brain injury: a revisited concept.[J].2001,16(3).
- [4]T, Kossmann,V H, Hans,H G, Imhof,etc.Intrathecal and serum interleukin-6 and the acute-phase response in patients with severe traumatic brain injuries.[J].1995,4(5).
- [5]王忠诚主编.神经外科学[M].1998.
- [6]Yamane K,Kohno N,Kamei N,etc.Elevated C-reactive protein is a risk factor for the development of type 2 diabetes in Japanese americans.[J].2003,26(10).
- [7]R J, Hariri,V A, Chang,P S, Barie,etc.Traumatic injury induces interleukin-6 production by human astrocytes.[J].1994,636(1).
- [8]Ristow M,Pfeiffer AF,Hoffmann K,etc.Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study.[J].2003,52(3).
- [9]Combs TP,Berg AH,Obici S,etc.Endogenous glucose production is inhibited by the adipose-derived protein Acrp30.[J].2001,108(12).
- [10]Wilcockson DC,Perry VH,Anthony DC,etc.The systemic and local acute phase response following acute brain injury.[J].2002,22(3).
- [11]Noriyuki Ouchi,Shinji Kihara,Tohru Funahashi,etc.Reciprocal Association of C-Reactive Protein With Adiponectin in Blood Stream and Adipose Tissue[J].2003,107(5).