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Effect on intestine by cobra venom factor in traumatic hemorrhagic shock rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1671-0282.2007.06.002
- Key Word:
- 创伤失血性休克;二胺氧化酶;眼镜蛇毒因子;内毒素移位;肠道损伤
Abstract： 目的 观察眼镜蛇毒因子(CVF)抑制补体激活对创伤失血性休克大鼠肠道的影响.方法 雄性SD大鼠建立创伤失血性休克模型,随机分成对照组和CVF组,根据观察时间点的不同各组再分为休克前、复苏后1、6、24 h时相组.结果 对照组大鼠复苏后1 h血总补体活性(CH50)水平迅速下降,血内毒素(LPS)浓度、肠黏膜损伤评分均明显升高,随后2个时间点快速恢复至休克前水平;二胺氧化酶(DAO)活性在随后1 h和6 h时相明显升高,然后快速下降.CVF组大鼠除CH50水平始终＜5%,其余各指标复苏后1 h仅略升高,其复苏后各时相组均较对照组相应时相组明显降低.结论 在创伤失血性休克中使用补体抑制剂可明显减轻补体激活导致的肠道损伤及肠屏障破坏,减少内毒素移位的发生,明显降低血浆内毒素含量.
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