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The protective effects of angiotensin-converting enzyme inhibitor (ACEI) on the heart in sepsis rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1671-0282.2007.02.006
- Key Word:
- 脓毒症;脂多糖;血管紧张素Ⅱ;血管紧张素转化酶抑制剂
Abstract： 目的 研究脓毒症大鼠心脏功能、心肌力学的改变及血浆血管紧张素Ⅱ浓度变化,并探讨血管紧张素转化酶抑制剂(ACEI)对心脏的保护作用.方法 Wistar大鼠随机分为对照组(32只)、脂多糖(LPS)组(32只,予LPS 4 mg/kg静脉注射)及LPS+ACEI组(32只,予雅施达2 mg/kg连续灌胃3 d,第4天静脉注射LPS).各组动物均经右颈总动脉左心室内插管,监测左室功能变化,并于实验前(0点)及给药后2、4、6 h采血(每时间点8只)行血管紧张素Ⅱ、肌钙蛋白T(TNT)检测.结果 ①脓毒症状态下TNT显著升高,应用ACEI后明显降低[(1.30±0.53) μg/L vs (0.40±0.34) μg/L,P＜0.01)].②脓毒症状态下,血管紧张素Ⅱ浓度升高,且可被ACEI制剂雅施达抑制[(1223.27±483.72)ng/L vs(383.0±182.22)ng/L,P＜0.01)].③脓毒症状态下左心室收缩峰压(LVPP)、左心室压力上升(下降)最大速率(±dp/dt)均有不同程度变化,左心室舒张末期压(LVEDP)升高,应用ACEI可明显降低.结论 ①脓毒症可致大鼠心肌发生明显损伤,该损伤的发生可能和AngⅡ有关;②ACEI可明显改善脓毒症时的心肌损伤.
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