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Effects of δ opioid receptor agonist D-Ala2-D-Leu5-enkephalin on hemodynamics in rats with hemorrhagic shock
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1671-0282.2007.01.005
- Key Word:
- 失血性休克;DADLE;血流动力学;δ阿片受体激动剂
Abstract： 目的 探讨δ阿片受体激动剂D-Ala2-D-Leu5-enkephalin(DADLE)对失血性休克大鼠血压和心功能的影响.方法 36只健康SD大鼠,随机分成假手术组、休克对照组和DADLE组(1mg/kg组和5 mg/kg组),休克对照组和DADLE组大鼠放血使MAP降至40 mmHg,维持低血比状态(MAP=40 mmHg)60 min后,用生理盐水或DADLE复苏,观察复苏后3 h内动脉血压(SAP、DAP和MAP)和心功能指标(LVSP、±dp/dtmax)的变化.结果 休克对照组复苏后各时点动脉血压和心功能指标呈逐渐下降趋势.DADLE组复苏后5 min动脉血压和心功能指标开始升高,30 min达高峰,复苏后同一时点各项指标均显著高于对照组(P＜0.01),其中1 mg/kg组和5 mg/kg组没有显著差异.结论 DADLE能改善失血性休克大鼠的血流动力学指标.
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