You Position: Home > Paper
Effects of continuous adenosine infusion on cardiac microcirculation in asphyxia Wistar rats during cardiopulmonary resuscitation (CPR)
( views:227, downloads:12 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1671-0282.2007.01.003
- Key Word:
- 心肺复苏术;肾上腺素;腺苷;微循环
Abstract： 目的 观察腺苷在窒息大鼠心肺复苏中对复苏成功率和心肌微循环的影响.方法 采用窒息法制作大鼠窒息模型,将实验动物随机分为对照组(A组)、肾上腺素组(B组)和肾上腺素合并腺苷组(C组).持续窒息3 min后,行胸外心脏按压,呼吸机辅助呼吸,4 min后静脉给药.A组(n=15)不用复苏药物;B组(n=14)静脉注射肾上腺素90 μg·kg-1;C组(n=14)静脉注射肾上腺素90 μg·kg-1并持续静滴腺苷70 μg·kg-1·min-1至复苏结束.观察自主循环恢复率、复苏成功率和心肌微循环.结果 C组自主循环恢复率(92.9%)和复苏成功率(64.3%)＞B组(78.6%,50%)＞A组(60%,20%);C组心肌毛细血管数目和面积好于A组和B组.结论 心肺复苏时肾上腺素合并腺苷可能会减轻肾上腺素部分负作用,改善大鼠心肌微循环,提高复苏成功率.
- [1]李丹阳,赵葵,陈鹏.碱性成纤维细胞生长因子、腺苷对兔急性心肌梗死后血管再生的影响[J].2004,(1).
- [2].窒息法致大鼠心脏骤停模型复苏的影响因素[J].2005,(10).
- [3]武建军,计达,郝秀华,等.大鼠窒息心脏骤停期间脑皮质β肾上腺素能受体和血中NO的变化[J].2005,(6).
- [4]Grover GJ,Garlid KD.ATP-Sensitive potassium channels: a review of their cardioprotective pharmacology.[J].2000,32(4).
- [5]Fujita A,Kurachi Y.Molecular aspects of ATP-sensitive K+ channels in the cardiovascular system and K+ channel openers.[J].2000,85(1).
- [6]Granger CB,Gibbons RJ,Califf RM,etc.Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial.[J].1999,34(6).
- [7]C G, Brown,H A, Werman,E A, Davis,etc.The effects of graded doses of epinephrine on regional myocardial blood flow during cardiopulmonary resuscitation in swine.[J].1987,75(2).
- [8]Bin JP,Le DE,Jayaweera AR,etc.Direct effects of dobutamine on the coronary microcirculation: comparison with adenosine using myocardial contrast echocardiography.[J].2003,16(8).
- [9]Sato S.Vasopressin with delayed combination of nitroglycerin increases survival rate in asphyxia rat model.[J].2002,54(3).
- [10]R A, Berg,C W, Otto,K B, Kern,etc.High-dose epinephrine results in greater early mortality after resuscitation from prolonged cardiac arrest in pigs: a prospective, randomized study.[J].1994,22(2).
- [11]Z Q, Zhao,S, McGee,K, Nakanishi,etc.Receptor-mediated cardioprotective effects of endogenous adenosine are exerted primarily during reperfusion after coronary occlusion in the rabbit.[J].1993,88(2).
- [12]Deindl E,Sommerschild HT,Kirkeboen KA,etc.Elevated levels of endogenous adenosine alter metabolism and enhance reduction in contractile function during low-flow ischemia: associated changes in expression of Ca(2+)-ATPase and phospholamban.[J].1999,31(10).
- [13]W.W. Nichols,F.A. Nicolini,B.C. Yang,etc.Adenosine protects against attenuation of flow reserve and myocardial function after coronary occlusion and reperfusion[J].1994,127(5).
- [14]Kahan T,Kjerr AC,Sollevi A,etc.Left ventricular function and cardiovascular events following adjuvant therapy with adenosine in acute myocardial infarction treated with thrombolysisResults of the ATTenuation by Adenosine of Cardiac Complications (ATTACC) study.[J].2003,59(1).