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Protective effects of lipoxin A4 on lipopolysaccharide-induced acute lung injury in rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 11
- DOI:
- 10.3760/j.issn:1671-0282.2006.11.002
- Key Word:
- 脂氧素A4;内毒素;血红素氧合酶;急性肺损伤
Abstract： 目的 探讨脂氧素A4对脂多糖诱导小鼠急性肺损伤的影响.方法36只雄性C57BL/6小鼠,随机分为对照组、脂氧素A4组、ZnPP组、内毒素组、脂氧素A4治疗组(LXA4+LPS)和ZnPP+脂氧素A4治疗组(ZnPP+LXA4+LPS),每组6只.雾化吸入脂多糖8 h后,测定肺泡灌洗液白细胞计数、中性粒细胞计数和TNF-α含量.测定肺组织髓过氧化物酶(MPO)活性、HO-1的蛋白表达和活性.结果 与LPS组比较,脂氧素A4治疗组肺组织中性粒细胞浸润减少,MPO活性、TNF-α浓度均降低(P＜0.01),肺组织损伤减轻,而HO-1的蛋白表达和活性明显升高,HO-1抑制剂ZnPP减弱脂氧素A4的保护作用.结论 脂氧素A4能减轻内毒素诱导的急性肺损伤.
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