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Protective effects of sodium ferulate on acute lung injury induced by paraquat in rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 7
- DOI:
- 10.3760/j.issn:1671-0282.2006.07.006
- Key Word:
- 百草枯;急性中毒;阿魏酸钠
Abstract： 目的探讨阿魏酸钠(sodium ferulate,SF)对百草枯(paraquat,PQ)中毒致大鼠急性肺损伤的治疗作用及其可能机制.方法大鼠一次性腹腔注射PQ 15 mg/kg,染毒同时及染毒后不同时间腹腔注射SF,分别测定染毒后8、24、48、72 h时点的大鼠血浆和肺组织匀浆中的肿瘤坏死因子(TNF-α)及内皮素(ET)含量,并观察肺组织结构变化.结果与正常对照组相比,大鼠染毒后8 h血浆TNF-α、ET含量及肺组织中的ET含量明显升高(P＜0.01),中毒后24 h肺组织中的TNF-α含量开始显著升高(P＜0.01),并持续升高至染毒后72 h,其中血浆TNF-α含量于染毒后48 h达峰值.给予SF治疗后与相应的中毒组比较,SF治疗8 h后血浆和肺组织中ET含量显著降低(P＜0.05),24 h后血浆和肺组织中TNF-α含量开始明显降低(P＜0.05).肺组织病理学检查可见PQ中毒后肺泡壁增厚、血管扩张、充血,巨噬细胞浸润,肺泡腔内有大量浆液渗出;SF治疗后肺泡壁毛细血管扩张、充血减轻,肺泡腔浆液性渗出明显减少.结论SF对急性PQ中毒有治疗作用,其作用机制与抑制介导PQ中毒后大鼠急性肺损伤的TNF-α因子及ET有关.
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