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Changes of electrocardiogram in circulatory failure dogs induced by sarin, soman, tabun and VX
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 7
- DOI:
- 10.3760/j.issn:1671-0282.2006.07.003
- Key Word:
- 胆碱酯酶抑制剂;心电图;神经性毒剂;循环衰竭
Abstract： 目的在胆碱酯酶抑制剂(cholinesterase inhibitor,ChEI)类神经性毒剂沙林、梭曼、塔崩和维埃克斯(VX)所致犬循环衰竭模型上,观察循环衰竭前后动物心电图变化的特征.方法健康成年雄性杂种犬40只,体重11～16 kg,随机分为4组:梭曼、沙林、塔崩和VX组,每组10只.观察犬循环衰竭过程中的心电图变化.结果ChEI类神经性毒剂诱发循环衰竭时可出现Ⅰ度、Ⅱ度、Ⅲ度房室传导阻滞,房性和室性早搏,室性心动过速,心室扑动,心室颤动,心房扑动,心房颤动,窦性心动过缓,窦性心动过速,窦性停搏等各种心律失常.在导致休克的缓慢性心律失常中,Ⅱ度Ⅱ型及Ⅲ度房室传导阻滞(AVB)占91.6%,窦性心动过缓及窦性停搏占8.4%.心电图发生T波高耸和P波增幅的特征性变化.结论ChEI类神经性毒剂中毒诱发循环衰竭时,可出现各种心律失常,其中以房室传导阻滞最常见,心电图常发生T波高耸和P波增幅的特征性变化.
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