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Effects of vitamins A, E, and C with total parenteral nutrition (TPN) on antioxidation in peritoneal sepsis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1671-0282.2006.05.005
- Key Word:
- 维生素;脓毒症;抗氧化能力
Abstract： 目的观察完全胃肠外营养(TPN)添加维生素A、E、C对腹腔感染后抗氧化能力的影响.方法采用盲肠结扎加穿孔(CLP)模型,将SD大鼠随机分为对照组(CLP+TPN)、治疗组(CLP+TPN+维生素A、E、C)、延迟治疗组(CLP+TPN+延迟应用维生素A、E、C),于术后当天以及第1、3、5天观察血浆及肝组织中维生素含量及丙二醛(MDA)、还原型谷胱甘肽(GSH)的变化.结果 CLP对照组维生素A、E、C及GSH明显低于正常对照,MDA显著高于正常对照;治疗组和延迟治疗组维生素A、E、C及GSH显著高于对照组,但延迟治疗组低于治疗组;治疗组和延迟治疗组MDA明显低于对照组,但延迟治疗组高于治疗组.结论 TPN添加维生素A、E、C能改善腹腔感染后机体的抗氧化能力,减轻脂质过氧化损伤.
- [1]李自力,李培杰,陈天铎,等.急性一氧化碳中毒患者血清丙二醛、超氧化物歧化酶和谷胱甘肽过氧化物酶水平变化及维生素C的干预作用[J].2003,(6).
- [2]Hotchkiss RS,Buchman TG,Turnbull IR,etc.Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.[J].2003,19(4).
- [3]Avery Nathens,Margaret Neff,Gregory Jurkovich,etc.Randomized, Prospective Trial of Antioxidant Supplementation in Critically Ill Surgical Patients[J].2002,236(6).
- [4]Long CL,Maull KI,Krishnan RS,etc.Ascorbic acid dynamics in the seriously ill and injured.[J].2003,109(2).
- [5]Shenkin A..Micronutrients in the severely-injured patient[J].2000,59(3).
- [6]Jennine M, Lunetta,Rebecca A, Zulim,Stephen R, Dueker,etc.Method for the simultaneous determination of retinol and beta-carotene concentrations in human tissues and plasma.[J].2002,304(1).