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Effects of mild hypothermia on NMDAR1 expression in cerebral subcortex after CPR in rats

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF EMERGENCY MEDICINE
Issue:
1
DOI:
10.3760/j.issn:1671-0282.2006.01.007
Key Word:
亚低温;心肺复苏;额叶皮层

Abstract: 目的探讨亚低温对心肺复苏大鼠大脑额叶皮层NMDAR1表达的影响.方法应用半定量RT-PCR方法观察亚低温对心肺复苏大鼠大脑额叶皮层NMDAR1表达的改变.结果亚低温组大鼠大脑额叶皮层NMDAR1mRNA和蛋白质水平表达明显降低,与常温治疗组比较差异有显著性(P<0.05).结论亚低温能够减轻心肺复苏后脑水肿,其机制可能为亚低温通过减少NMDAR1在mRNA和蛋白质水平的表达、降低阳离子通道通透性的作用,而减轻脑水肿的形成,起到治疗心肺复苏后脑水肿的作用.

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