You Position: Home > Paper
The role and significance of nuclear factor-kappa B activity after cardiopulmonary-cerebral resuscitation
( views:215, downloads:12 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1671-0282.2006.01.005
- Key Word:
- 心肺脑复苏;复苏;多脏器功能障碍综合征
Abstract： 目的观察心搏骤停患者经心肺脑复苏(CPCR)后核因子κB(NF-κB)活性和肿瘤坏死因子-α(TNF-α)水平的变化及意义.方法以电泳迁移率变动分析法(EMSA)检测外周血单个核细胞的NF-κB活性,放射免疫法测定血清TNF-α水平.结果NF-κB活性、TNF-α水平和APACHEⅡ评分在复苏后多脏器功能障碍综合征(PR-MODS)组和死亡组分别明显高于非PR-MODS组和存活组(P＜0.05);NF-κB活性、TNF-α水平和APACHEⅡ评分均呈正相关(P＜0.05).结论心搏骤停和CPCR过程可以使NF-κB激活、TNF-α表达增加,这对PR-MODS的发生、病情轻重具有重要决定作用.
- [1]廖晓星,苏全冠,马中富.院内复苏Utstein模式的临床应用[J].2001,(6).
- [2]李欣,廖晓星.核因子κB在全身炎症反应综合征和多器官功能障碍综合征中的作用[J].2002,(5).
- [3]Alexander,Geppert Gerlinde,Zorn Georg,etc.Soluble selectins and the systemic inflammatory response syndrome after successful cardiopulmonary resuscitation[J].2000,28(7).
- [4]Wigginton JG,Persse DE,Zachariah BS.Managing the post-resuscitation patient in the field.[J].2002,6(1).
- [5]S, Foulds,C, Galustian,A O, Mansfield,etc.Transcription factor NF kappa B expression and postsurgical organ dysfunction.[J].2001,233(1).