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The effects of recombinant human growth hormone on protein anabolism in elderly thoracic trauma patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 11
- DOI:
- 10.3760/j.issn:1671-0282.2005.11.007
- Key Word:
- 生长激素;代谢;肠内营养;胸部外伤;握力
Abstract： 目的研究应用重组人生长激素(rhGH)对接受常规肠内营养支持的胸部外伤老年患者蛋白质代谢的调理作用.方法选择20例多发性肋骨骨折(肋骨骨折3根以上)、年龄大于70岁的老年患者20例,随机分为两组.治疗组10例,采用标准肠内营养+rhGH(rhGH 每天12 U皮下注射,共计8 d);另外10例作为对照组,仅应用肠内营养治疗.两组患者其他治疗完全相同.治疗前和治疗后的第8天,分别测定血清白蛋白、血清转铁蛋白、血清前白蛋白浓度和双手握力,统计医院获得性肺炎的发生情况.结果治疗组患者在治疗后第8天的血清白蛋白、血清转铁蛋白和血清前白蛋白水平比对照组显著升高(P＜0.05),双手握力与对照组相比有显著增强(P＜0.01);治疗组患者医院获得性肺炎的发生率也较对照组显著降低(P＜0.05).结论老年胸部外伤患者蛋白质的合成能力较差,在肠内营养支持下加用rhGH可以明显促进老年患者蛋白质合成代谢,增加肌肉的收缩力,增强排痰力度,减少医院获得性肺炎的发生率.
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