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Factors influencing asphyxial cardiac arrest
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 10
- DOI:
- No doi available
- Key Word:
- 心肺复苏;心脏停搏;窒息;模型;大鼠
Abstract： 目的观察心肺复苏(CPR)效果,并探讨窒息时间及CPR时间对大鼠自主循环恢复(ROSC)率和6 h生存率的影响.方法采用呼气末夹闭气管窒息法,建立大鼠心脏停搏(A)模型.30只Sprague Dawley(SD)大鼠随机分2组,窒息7 min组(n=15),窒息9min组(n=15).观察大鼠窒息及心肺复苏期间平均动脉压(MAP)、心电图(ECG)、心率(HR)和动脉血pH值的变化,比较各组的ROSC率和6 h生存率.结果窒息7 min组ROSC率和6h存活率与窒息9 min组比较,差异无显著性(P＞0.05);CPR时间＜5 min者6 h生存率显著高于CPR时间＞5 min者(P＜0.05);存活时间大于6 h者CPR时间与存活时间小于6 h者CPR时间比较有显著性差别(P＜0.05).结论该复苏模型制作简单,重复性好,可观察多个指标,能满足心肺复苏实验研究的需要;窒息时间选择应控制在7～9 min以内;CPR时间是预测CPR成功率的重要指标.
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