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Relationship between coagulation disorders and severity and prognosis in severe sepsis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 10
- DOI:
- No doi available
- Key Word:
- 重度脓毒症;血小板;D-dimer;PT APTT;TT;APACHE-Ⅱ评分
Abstract： 目的探讨重度脓毒症凝血功能紊乱与病情严重度及预后的关系.方法将2002年11月至2005年3月收住全国20家三级医院脓毒症并发急性器官功能不全患者694例分为死亡组和生存组,分析比较两组患者主要凝血指标的差异及主要凝血指标异常与病情严重度(APACHE-Ⅱ评分)的关系.结果(1)死亡组患者与凝血功能相关的主要指标:血小板明显低于存活组(P＜0.05),D-dimer明显高于生存组(P＜0.05),凝血酶元时间(PT)、部份凝血活酶时间(APTT)、TT均较生存组延长(P＜0.05).(2)血小板下降、血小板下降与D-dimer同时升高,APTT和FDP异常患者的APACHE-Ⅱ评分明显高于生存组(P＜0.05).结论与凝血功能相关的主要指标:血小板、D-dimer、PT、APTT、TT的检测对判断重度脓毒症的预后及评估病情严重度有一定指导意义.
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