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Interleukin-6 sermn level and genotypes in patients with acute myocardial infarction
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 8
- DOI:
- 10.3760/j.issn:1671-0282.2005.08.005
- Key Word:
- 急性心肌梗死;白细胞介素-6;基因型
Abstract： 目的分析急性心肌梗死患者白细胞介素-6(IL-6)基因启动子-572C/G、-634C/G的多态性,探讨IL-6的基因型及其血清水平与急性心肌梗死的关系.方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)的分析方法,检测了128例急性心肌梗死患者和145例健康对照者IL-6基因多态性,同时采用酶联免疫吸附试验检测IL-6的血清水平.结果急性心肌梗死组IL-6水平显著高于对照组(P＜0.01),IL-6-572C/G基因型和等位基因频率在急性心肌梗死组和对照组比较,差异有显著性(P＜0.05),与健康对照组相比,发现G等位基因携带者患急性心肌梗死的的相对风险度增加1.740倍(OR=1.740,95%CI=1.135～2.668).携带G等位基因的急性心肌梗死患者血清IL-6水平显著高于不携带者(P＜0.01).IL-6基因-634C/G多态性在急性心肌梗死组和对照组之间比较差异无显著性(P＞0.05).结论IL-6基因-572C/G多态性与急性心肌梗死之间存在相关关系,其中G等位基因可能是急性心肌梗死发病的遗传易感基因;携带G等位基因的个体可能通过促进IL-6的高度表达进而增加了急性心肌梗死的发病风险.
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