You Position: Home > Paper
Effects of ischemic preconditioning on ventricular dilation-induced arrhythmias in isolated rat hearts
( views:349, downloads:4 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 8
- DOI:
- 10.3760/j.issn:1671-0282.2005.08.004
- Key Word:
- 缺血预适应;心律失常;室性早搏;室性心动过速;机械电反馈
Abstract： 目的观察缺血预适应对膨胀离体大鼠心室所致心律失常的影响.方法采用Langendorff方法灌流离体大鼠心脏.将可充灌液体的乳胶球囊通过左心房及二尖瓣置于左心室,通过向乳胶球囊注射液体对左室进行膨胀,记录膨胀前和膨胀过程中左室心电图和左室压力、冠脉流量和心率;并计算对照组和各实验组由膨胀诱发心律失常的发生率和持续时间.结果通过乳胶球囊膨胀左室,在左室舒张末压增加相同的情况下,缺血预适应组较对照组室性早搏和室性心动过速发生率均降低,持续时间显著缩短;加入维拉帕米、白屈菜赤碱或格列本脲后,室性早搏和室性心动过速发生率均增高,持续时间延长;单纯维拉帕米、白屈菜赤碱或格列本脲组心律失常发生情况和对照组相似.结论对大鼠心室进行膨胀可诱发心律失常;缺血预适应对心律失常的发生具有抑制作用;细胞内钙离子浓度的短暂升高可能是缺血预适应发挥抑制作用的驱动因子;ATP敏感性钾通道及蛋白激酶C在缺血预适应过程中可能发挥了重要作用.
- [1]程龙献,王志强,廖玉华,等.机械牵张对缺血预适应心肌动作电位的影响[J].2004,(8).
- [2]Hong K,Ohe T,Fujimoto Y,etc.Involvement of Ca(2+) in antiarrhythmic effect of ischemic preconditioning in isolated rat heart.[J].2000,50(2).
- [3]Breithardt G,Haverkamp W,Kirchhof P,etc.Load-induced changes in repolarization: evidence from experimental and clinical data.[J].2001,96(4).
- [4]Wang L,Hernandez L,Figueredo V,etc.Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channels.[J].2001,280(5).
- [5]Ninomiya H,Imamura H,Nakao S,etc.Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor.[J].2003,126(1).
- [6]Ayub A,Xu M,Ashraf M,etc.Calcium preconditioning inhibits mitochondrial permeability transition and apoptosis.[J].2001,280(2).
- [7]H, Miyawaki,M, Ashraf.Ca2+ as a mediator of ischemic preconditioning.[J].1997,80(6).