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Correlation between nuclear factor kappaB activation and prognosis in patients with systemic inflammatory response syndrome

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF EMERGENCY MEDICINE
Issue:
1
DOI:
10.3760/j.issn:1671-0282.2005.01.015
Key Word:
全身炎症反应综合征;核因子-κB;白介素-6;急性生理与慢性健康评分

Abstract: 目的观察全身炎症反应综合征(SIRS)患者核因子-κB(NF-κB)的活性、白介素-6(IL-6)水平及急性生理与慢性健康评分Ⅱ(APACHEⅡ)的变化,探讨NF-κB活性与SIRS患者病情及预后的关系.方法将35名SIRS患者按MODS的诊断标准和疾病的转归分别分成多器官功能障碍综合征组(MODS组)和非MODS组,存活组和死亡组;选择健康体检者20例作为对照组.检测外周血单个核细胞NF-κB的活性及血浆IL-6水平,并进行APACHEⅡ评分.结果SIRS患者的NF-κB活性和IL-6水平明显高于对照组(P<0.01);NF-κB活性,IL-6水平和APACHEⅡ评分在MODS组和死亡组分别明显高于非MODS组和存活组(P<0.01或P<0.05);NF-κB活性与IL-6水平及APACHEⅡ评分均呈明显正相关(r=0.754,r=O.737,P<0.01);IL-6水平与APACHEⅡ评分呈明显正相关(r=0.63,P<0.01).结论NF-κB活性与SIRS患者的病情及预后密切相关.

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