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Role of P38 MAPK and NFκB P65 in the acute lung injury induced by chest explosive trauma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1671-0282.2005.01.006
- Key Word:
- 胸部爆炸伤;急性肺损伤;P38丝裂原活化蛋白激酶;核转录因子κBP65
Abstract： 目的探讨P38丝裂原活化蛋白激酶(P38MAPK)和核转录因子κBP65(NFκBP65)活化在胸部爆炸伤致急性肺损伤(ALI)中的作用.方法应用胸部爆炸伤致ALI动物实验模型,原位分子杂交技术检测P38MAPK和NFκB P65mRNA表达情况,并与致伤后ALI发病程度进行相关性统计分析.结果肺组织中P38 MAPK和NFκB P65mRNA表达情况与PaO2,P(A-a)O2、TNF-α及IL-6水平呈正相关,与急性肺损伤肺炎症反应的严重程度存在一致性.结论P38MAPK和NFκB P65活化在胸部爆炸伤致急性肺损伤(ALI)中起着重要作用,设法减弱其活化程度可能是防治ALI的有效途径.
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