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The characteristics of intestinal mucosal barrier in rats resuscitated after hemorrhagic shock
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 10
- DOI:
- 10.3760/j.issn:1671-0282.2004.10.006
- Key Word:
- 失血性休克;缺血-再灌注;肠黏膜屏障
Abstract： 目的探讨失血性休克肠缺血-再灌注损伤后黏膜屏障的形态学、功能与重建的特点.方法制作大鼠失血性休克模型,于复苏后0、1、3、6、12、24 h时间段活杀并进行光镜和电镜下肠黏膜组织形态学观察、内毒素含量及尿液乳果糖/甘露醇比值的测定.结果肠黏膜主要表现为凋亡和坏死两种损伤形式,大部分肠黏膜于6 h重建,12 h结构基本恢复正常,肠杯状细胞数在各组呈下降趋势;内毒素和乳果糖/甘露醇比值在6 h达高峰.结论失血性休克后肠黏膜屏障早期受累,但同时具有快速重建能力;屏障功能的恢复滞后于形态学重建.
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