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The prevention and treatment of nonvalvular atrial fibrillation associated with ischemic stroke
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 9
- DOI:
- 10.3760/j.issn:1671-0282.2004.09.005
- Key Word:
- 非瓣膜性心房颤动;缺血性脑卒中;华法林;阿司匹林
Abstract： 目的探讨华法林和阿司匹林预防非瓣膜性心房颤动(房颤)并发缺血性脑卒中的有效性和安全性.方法 140例持续性房颤患者分为高危组和低危组:高危组患者100例,其中54例接受口服华法林治疗(INR目标值1.6～2.5),46例口服肠溶阿司匹林(100 mg/d)治疗;低危组40例口服肠溶阿司匹林(100 mg/d)治疗.结果高危组华法林的维持剂量(2.68±1.05)mg,INR值1.82～2.49,随访期间无缺血性脑卒中事件发生,3例发生出血并发症(INR 2.8～3.2);高危组阿司匹林治疗的1例患者发生缺血性脑卒中;低危组患者无1例发生缺血性脑卒中.结论低强度华发林抗凝治疗可有效预防非瓣膜性房颤高危患者缺血性脑卒中的发生,并减少出血并发症;阿司匹林(100 mg/d)可有效预防低危患者缺血性脑卒中事件的发生.
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