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The effect of mild hypothermia after preconditioning on myocardial infarction size in rabbits
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 9
- DOI:
- 10.3760/j.issn:1671-0282.2004.09.004
- Key Word:
- 亚低温;缺血预处理;心肌梗死
Abstract： 目的探讨心肌缺血预处理后亚低温治疗对家兔急性心肌梗死面积的影响.方法 14只家兔随机分为为常温组和亚低温组,结扎前降支建立急性心肌梗死模型.亚低温组通过物理降温使结扎后30 min体温降到35℃以下,常温组体温维持在38℃以上.取心脏染色切片,计算梗死心肌、濒危心肌和左室心肌的重量.结果 (1)亚低温组梗死心肌占濒危心肌的比例分别为[(32.7±6.5)%和(44.9±10.7),P=0.034];占左室心肌的重量比例分别为[(5.8±1.7)%和(9.4±2.0)%,P=0.005].(2)组织学检查显示亚低温组梗死心肌重量明显低于常温组,分别为(0.38±0.11)g和(0.59±0.14)g,P＝0.013].(3)亚低温组梗死后3h血清CK-MB活性改变与常温组相近[(3113.0±1351.8)U/L对(2733.4±1792.3)U/L,P=0.679].(4)亚低温组心电图胸前导联抬高幅度之和与常温组无显著性差异(51.4mV±19.4mV对41.0mV±27.6mV,P=0.457).结论心肌缺血预处理后给予亚低温治疗可减少家兔急性心肌梗死的面积.
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