Abstract： Objective Distal embolization during percutaneous coronary intervention (PCI) is associated with the significant increase in major adverse cardiac events (MACE). We evaluate the safety and efficacy of the combination of PCI and the PercuSurge Guardwire in the treatment of acute myocardial infarction patientsMethods Ninety-two AMI patients underwent emergent PCI either with the PercuSurge Guardwire (PercuSurge group) or without (control group).PercuSurge group had 47 patients with mean age (61.4±7.1) years, and control group 45 patients with mean age (64.9±8.3) years. Immediate blood flow after PCI and MACE at 30 day after PCI were compared.Results Stents and Guardwire were successfully applied in all patients. The mean diameter of occlusive balloon was (4.5±0.5) mm and the mean occlusive time was (8.7±5.9) min. Immediate blood flow was improved significantly in PercuSurge group compared to the control group.After the use of PercuSurge Guardwire,the complications included distal thromboembolism (2.13%) and coronary dissection (2.13%). The MACE during in-hospital and at 30-day follow-up of Precusurge group were significantly less than control group ( 2.13% vs 13.33 % and 2.13 % vs 8.89%, respectively, P＜0.05). Conclusions This study demonstrates the feasibility and safety of using the PercuSurge Guardwire system during PCI in AMI patients to prevent distal embolization.Immediate blood flow is significantly improved,and no-blood-flow rate is markedly reduced. MACE during in-hospital and at 30-day follow-up markedly decrease.