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Effects of transhinoneⅡA on genes expression related to aldosterone synthesis in spontaneously hypertensive rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 7
- DOI:
- 10.3760/j.issn:1671-0282.2004.07.007
- Key Word:
- 丹参酮ⅡA;醛固酮合成相关基因;CYP11B1;CYP11B2
Abstract： 目的探讨丹参酮ⅡA对心肌醛固酮合成相关基因表达的作用. 方法雄性自发性高血压大鼠(SHR)20只,分为两组:高血压组、丹参酮ⅡA组,分别腹腔注射生理盐水、丹参酮ⅡA12周.通过逆转录-聚合酶链反应,以GAPD H为内参照,测定两组心肌CYP11B1、CYP11B2的mRNA表达量.结果丹参酮ⅡA组CYP11B1及CYP11B2的mRNA表达水平明显低于高血压组(0.924±0.121 vs 1.3 43 ±0.132,P＜0.05;1.017±0.119 vs 1.675±0.126,P＜0.01),GAPDH的 mRNA水平在两组间无显著差异(P＞0.05).结论丹参酮ⅡA治疗可抑制心脏醛固酮合成相关基因CYP11B1及CYP11B2的mRNA表达.
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