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The effects of endotracheal dexamethasone on acute lung injury and ARDS
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1671-0282.2004.05.005
- Key Word:
- 急性肺损伤/急性呼吸窘迫综合征;气道内给药;地塞米松
Abstract： 目的探讨因创伤等引起的急性肺损伤(ALI)和急性呼吸窘迫综合征(ARDS)患者气道内给予地塞米松的治疗效果.方法64例符合ALI/ARDS诊断标准的患者,建立人工气道,行机械通气.充分湿化吸痰后,首次气道内注入10mg地塞米松,第1天气道内注入地塞米松5 mg/h,第2天注入5 mg/2h,第3天注入5 mg/h,3 d后逐日减为2.5 mg/4 h、2.5 mg/6h、2.5 mg/8h后停药;地塞米松全身用量为10～20 mg/d,2～3 d后停药.结果①呼吸机治疗气道峰值压力平均降低8.20 cmH2O;②动脉氧分压升高至61.90～93.00 mm Hg.结论气道内应用地塞米松能明显改善呼吸功能,阻止ALI病程向ARDS的发展.同时由于激素局部用药,减少大剂量激素用药不良作用.
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