Abstract： Objective To compare vascular closure device and conventional compression on vascular complications and patient satisfaction.Methods Four hundred and eighty three patients were performed PTCA by femoral approach, 298 patients received conventional compression device (Femostop) at the site of puncture, and 185 patients used vascular closure device (AngiosealTM in 162 cases, Perclose in23 cases). The time of hemostasis,the time of ambulation and vascular complications were recorded.Results The rates of using GP Ⅱ-6 Ⅲ a inhibitors in two groups were 56.8%, 18.8%, respectively ( P ＜ 0.001 ). The time of hemostasis using Angio- sealTM, Perclose, Femostop was (1.7±1.2) min (P＜0.0001), (13.7±6.1) min (P＜0.001), (115.7 ± 35.3) min respectively. The time of early ambulation was (4.1±2.4) h (P＜0.01), (7.6±8.2) h (P＜ 0.05 ), ( 10.7 ± 4.3 ) h respectively. The incidences of vascular complications was 1.9% (P ＜0.005), 13.0%, 6.4%(P ＜ 0.05 ), respectively. The overall incidences of vascularcomplications in two groups were 3.2% and 6.4% (P ＞ 0.05),the patient satisfaction of 48 h following-up in two groups were 92.4%, 65.4% (P ＜ 0.0001), the stay in hospital were (23.1±12.3) h, (22.8±12.3) h, respectively (P＞0.05), and there was no significant difference between two groups.Conclusion The use of vascular closure device enables early ambulation and reduce hospital stay for the patients. With AngioSealTM, the success rate and patient satisfaction are the best, and vascular complication is the least.