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The variation of peripheral blood dentitic cell in patients with severe multiple trauma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1671-0282.2004.04.003
- Key Word:
- 多发伤;树突状细胞;免疫学
Abstract： 目的探讨严重多发伤后患者早期外周血树突状细胞(DC)的变化.方法自严重多发伤患者(24例,多发伤组)和健康人(13例,对照组)外周血分离出树突状细胞;通过流式细胞仪检测各组的DC数量(CMRF-44标记法)及DC表面HLA-DR、CD80、CD86表达水平以及DC诱导的T细胞反应性增殖.结果多发伤组DC数量[(7.3±3.4)×106/L]明显低于对照组DC数量[(14.1±5.3)×106/L],P＜0.01.多发伤组DC表面HLA-DR及CD80、CD86的表达水平与对照组相比明显下调(P＜0.01).DC诱导的T细胞增殖能力多发伤组明显低于对照组(P＜0.01).结论严重多发伤患者早期外周血DC数量少,功能低下,与创伤早期免疫功能低下有关.
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