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Acute lung injury induced by lipopolysaccharides and imbalance of Th1/Th2 cytokines
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1671-0282.2004.02.005
- Key Word:
- 急性肺损伤;Th1/Th2;内毒素;细胞因子
Abstract： 目的探讨内毒素诱导的肺损伤与Th1/Th2平衡的关系.方法采用颈静脉注入,LPS复制大鼠急性肺损伤模型,用ELISA法检测其外周血单个核细胞(PBMC)产生IFN-γ、IL-4水平及IFN-γ/IL-4比值.结果与正常对照组相比,急性肺损伤组外周血PBMC产生IFN-γ水平和IFN-γ/IL-4比值明显升高(P＜0.05;P＜0.001),而IL-4水平差异无显著性(P＞0.05),肺组织病理切片显示大鼠发生ALI.结论 LPS诱导的肺损伤,体内存在Th1/Th2类细胞因子水平失衡.
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