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Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in infant rats meconium aspiration lung injury

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF EMERGENCY MEDICINE
Issue:
12
DOI:
10.3760/j.issn:1671-0282.2003.12.008
Key Word:
重组人超氧化物歧化酶;一氧化氮吸入;胎粪;急性肺损伤

Abstract: 目的探讨联合应用重组人超氧化物歧化酶(recombinant human superoxide dismatase,rhSOD)和一氧化氮吸入(inhaled nitric oxide,iNO)对胎粪诱导幼鼠急性肺损伤的保护作用及可能机制.方法 32只雄性SD幼年大鼠,通过气管置管注入20%胎粪1 ml/kg建立幼鼠胎粪性肺损伤模型,随机分为:(1)对照组(Control,C):暴露于空气中;(2)NO吸入组(iNO):暴露于20×10-6NO中;(3)rhSOD组(SOD)):rhSOD 20 mg/kg*ml气管内注入并暴露于空气中;(4)联合应用20×10-6NO和20 mg/kg rhSOD组(iNO/SOD),暴露24 h后观察支气管肺泡灌洗液(bronchoalveolar lavage fluid,BALF)细胞数、肺组织匀浆髓过氧化物酶(myeloperoxidase,MPO)活性、丙二醛(malonyldialdehyde,MDA)、一氧化氮(nitric oxide,NO)含量和肺损伤病理改变.结果与对照组比较,iNO组、SOD组BALF细胞数、MPO活性、肺损伤病理评分下降(P<0.05或0.01)、iNO/SOD组较iNO组BALF细胞数、MPO活性进一步降低(均P<0.05);但肺损伤病理评分差异无显著牲;与对照组比较,iNO组肺组织MDA、NO含量略有下降,但差异无意义(均P>0.05),SOD组、iNO/SOD组肺组织MDA、NO含量显著下降(P<0.05或0.01),且iNO/SOD组显著低于iNO组(P均<0.05).结论 rhSOD可以加强iNO对幼鼠胎粪吸入性肺损伤的抗炎和肺损伤保护作用.

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