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The protective effects of Jieduhuayu decoction on vascuar endothelium cells in rats with multiple organ dysfunction syndrome
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 10
- DOI:
- 10.3760/j.issn:1671-0282.2003.10.003
- Key Word:
- 解毒化瘀汤;多脏器功能障碍综合征;血管内皮细胞
Abstract： 目的探讨解毒化瘀汤对多器官功能障碍综合征(MODS)大鼠血管内皮细胞的保护作用.方法将52只Wistar大鼠随机分为对照组、模型组,以及低、中、高剂量中药组共5组.尾静脉注射内毒素方法制作MODS鼠模型,中药组每日用解毒化瘀汤灌胃1次,对照组每日用相同剂量的饮用水灌胃1次,第4天取血,以硝基四氮唑蓝(NBT)法查中性粒细胞(PMN)活化计数,用酶联免疫吸附(ELISA)法查血管性血友病因子(vWF)及血栓调节蛋白(TM)值.结果模型组及低、中、高剂量中药组的vWF、TM值和PMN活化计数水平均明显高于对照组(P＜0.05),低、中、高剂量中药组vWF、TM值和PMN活化计数水平均明显低于模型组(P＜0.05),3项指标间两两呈正相关.结论 MODS大鼠模型制作成功,解毒化瘀汤对MODS大鼠血管内皮细胞具有保护作用.
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