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Effect of GLP-2 on intestinal immunity of the rat following hemorrhagic shock and resuscitation
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 9
- DOI:
- 10.3760/j.issn:1671-0282.2003.09.005
- Key Word:
- GLP-2;sIgA;内毒血症
Abstract： 目的研究高血糖素样肽-2(Glucagon-like peptide-2,GLP-2)对大鼠失血性休克复苏后胆汁中分泌型IgA(sIgA)、肠黏膜蛋白质和DNA含量的影响.方法采用大鼠经股动脉放血及自体血回输的方法复制休克复苏模型,连续腹腔注射GLP-2,7 d后收集大鼠胆汁测定sIgA、采集门静脉血测定血内毒素及制备小肠黏膜标本测定小肠黏膜蛋白质和DNA含量.结果休克复苏组胆汁中sIgA仅为对照组的78%左右,而GLP-2组与对照组接近;小肠黏膜蛋白质和DNA含量GLP-2组显著高于休克复苏组,门静脉血内毒素也显著减少.结论 GLP-2能够改善大鼠休克复苏后肠道免疫功能,从而减轻内毒血症.
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