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The role of leukocytes in post-traumatic cardiac dysfunction
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 8
- DOI:
- 10.3760/j.issn:1671-0282.2003.08.008
- Key Word:
- 创伤性休克;中性粒细胞;炎症;多器官功能衰竭综合征
Abstract： 目的探讨创伤后心肌组织是否存在着白细胞浸润,并研究白细胞在心脏功能不全中的作用.方法麻醉后的雄性小鼠被随机分为创伤组和对照组(25只/组),在创伤后6 h测定两组小鼠平均动脉压(MAP)、心脏功能指标和心肌组织髓过氧化物酶(MPO)活性.结果创伤组小鼠出现了明显的低血压和心脏功能不全[创伤组平均动脉压(MAP)、等容收缩期室内压最大变化速率(+dp/dtmax),心脏指数(CI)分别为(70±9)mmHg,(3492±276)mmHg/s,(62±6)ml/min/100g;对照组分别为(90±8)mmHg,(4745±219)mmHg/s,(72±7)ml/min/100g,P＜0.05];创伤组小鼠心肌组织MPO活性明显增高[创伤组为(8.46±1.70)U/100mg,对照组为(4.52±0.94)U/100mg,P＜0.05],且MPO活性与心脏功能呈明显负相关.结论创伤后心肌组织的炎症反应是导致创伤后心功能不全的一个重要因素,提示抗炎治疗对于改善创伤后心功能不全具有潜在的治疗价值.
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