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The pathogenicity of vibrio vulnificus and effects of antimicrobial agents
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 8
- DOI:
- 10.3760/j.issn:1671-0282.2003.08.007
- Key Word:
- 创伤弧菌;感染;致病性;抗菌药物
Abstract： 目的研究创伤弧菌的致病性和抗菌药物的治疗作用.方法创伤弧菌腹腔注射感染小鼠后0.5 h,分别腹腔注射奈替米星等7种抗菌药物进行治疗.观察不同菌量下小鼠的存活率及死亡小鼠脏器超微结构变化.结果创伤弧菌菌量1.5×108cfu/ml(0.1ml/10g)、2倍、4倍感染小鼠存活率分别为80%、30%、0.小鼠的多脏器的超微结构发生明显改变,7种抗菌药物早期均有显著疗效,以哌拉西林、头孢哌酮、奈替米星疗效最好.结论小鼠感染创伤弧菌菌量越大,致病性越强,及早足量应用抗菌药物对治疗感染有较好疗效.
- [1]李秉煦,吴慧珍,卢中秋,等.原发性创伤弧菌感染12例[J].2001,(2).
- [2]J H, Bowdre,J H, Hull,D M, Cocchetto.Antibiotic efficacy against Vibrio vulnificus in the mouse: superiority of tetracycline.[J].1983,225.
- [3]K C, Klontz,S, Lieb,M, Schreiber,etc.Syndromes of Vibrio vulnificus infections. Clinical and epidemiologic features in Florida cases, 1981-1987.[J].1988,109.