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Study of alterations of tissue oxygen extraction ratio in rabbits with septic shock
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1671-0282.2003.05.002
- Key Word:
- 败血症;休克;小肠黏膜;氧摄取率;微循环
Abstract： 目的探讨感染性休克时新西兰大白兔全身和空肠氧摄取率变化的规律.方法应用大肠杆菌内毒素制备兔感染性休克模型.对照组(n＝5只,注射等量生理盐水)和感染性休克组(n＝10只),分别做右侧颈外静脉至右心房、股动脉、肠系膜上静脉近端分支插管、抽血行血气分析,观察两组不同时间段全身和空肠氧摄取率及血气参数的变化.结果感染性休克组全身氧摄取率似有增加,但与对照组相比,差异无显著性意义(P＞0.05);而小肠氧摄取率逐渐增加,与基础值和对照组相比,差异有显著性意义(P＜0.05);右心房血(混合静脉血)和肠系膜上静脉近端血pH随休克时间延长逐渐降低,BE负值逐渐增大,两者呈平行关系,与基础值和对照组相比,差异有显著性意义(P＜0.05).结论感染性休克时,全身氧摄取率不变,空肠局部氧摄取率增加,但组织缺氧始终存在,测定全身氧代谢不能代表局部氧代谢.
- [1]E, Ruokonen,J, Takala,A, Kari,etc.Regional blood flow and oxygen transport in septic shock.[J].1993,21.
- [2]A D, M?ller,P O, Gr?nde.Beneficial effects of low-dose prostacyclin on cat intestinal perfusion during endotoxemia as evaluated with microdialysis and oxygen transport variables.[J].2001,29.
- [3]Zhang H,Smail N,Cabral A,etc.Effects of norepinephrine on regional blood flow and oxygen extraction capabilities during endotoxic shock.[J].1997.
- [4]朱愉，多秀瀛主编.实验动物的疾病模型[M].1997.
- [5]Ba,ZF,Wang,P,Koo,DJ,etc.Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shock (see comments)[J].2000,28(8).
- [6]Haibo Zhang,Raf De Jongh,Daniel De Backer,etc.Effects of &agr; - and &bgr; -adrenergic stimulation on hepatosplanchnic perfusion and oxygen extraction in endotoxic shock[J].2001,29(3).