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The study of plasma C-reactive protein and the 1059G/C polymorphism in patients with acute coronary syndrome
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1671-0282.2003.04.002
- Key Word:
- 急性冠脉综合征;C-反应蛋白;基因;多态性
Abstract： 目的探讨中国汉族人群中C-反应蛋白(C-reactive protein,CRP)及其1059G/C基因多态性与急性冠状动脉综合征(acute coronary syndrome,ACS)的关系.方法测定113例ACS患者(包括不稳定性心绞痛、急性心肌梗死)和109例对照组(非ACS,包括稳定性心绞痛、陈旧性心肌梗死)的CRP、纤维蛋白原(fibrinogen,Fbg)水平,并应用聚合酶链反应-限制性片段长度多态性(PCR-RELP)技术检测CRP的1059G/C基因多态性,结合冠状动脉造影结果进行分析.结果 ACS组的CRP水平显著高于对照组(P＜0.05),且冠状动脉3支病变和2支病变患者血清CRP水平亦均高于1支病变(P＜0.05);但是Fbg水平与ACS和冠状动脉病变支数无关(P＞0.05).CRP 1059G/C基因型和等位基因的频率分布符合Hardy-Weinberg平衡(P＞0.05).ACS组和对照组CRP 1059G/C基因型和等位基因的分布趋势相同,差异无显著性意义(P＞0.05).(GC+CC)基因型的血清CRP水平显著低于GG基因型(P＜0.05).结论血浆CRP水平升高可能是ACS发生的一种预测指标;CRP水平可能受其1059G/C基因多态性的影响.
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