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Experimental study on myocardial ischemia and collateral recruitment after acute coronary occlusion by myocardial contrast echocardiography
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1671-0282.2003.03.006
- Key Word:
- 心肌声学造影;冠脉闭塞;心肌缺血;侧支循环
Abstract： 目的探讨经静脉心肌声学造影在动态评价犬急性冠状动脉闭塞时缺血、坏死心肌,及侧支循环逐步建立开放中的价值.方法7只健康杂种犬,分别于基础状态,左冠前降支(LAD)结扎即刻、结扎后3 h行经静脉心肌声学造影(MCE).定量分析冠脉闭塞后心肌低灌注区视频密度峰值(Ⅵ),测量充盈缺损区面积,监测血流动力学变化.结果1只犬于LAD结扎2 min时因发生室颤死亡,统计分析时剔除,其余6只犬经静脉MCE未见血流动力学影响.LAD结扎3 h的造影充盈缺损面积小于结扎即刻(P＜0.001);LAD结扎3 h的心肌低灌注区视频密度峰值较结扎即刻明显增加(P＜0.001);心肌病理染色确定的坏死心肌部位在MCE的充盈缺损范围内.结论MCE是反映心肌血流灌注的安全、有效方法,可准确评价冠脉急性闭塞时心肌血流灌注的变化及侧支循环状态.
- [1]谢志泉,刘伊丽,查道刚,等.缺血预适应：心肌声学造影的评价及心肌灌注动态变化特征[J].1999,(5).
- [2]F, Khaja,H G, Sabbah,J F, Brymer,etc.Influence of coronary collaterals on left ventricular function in patients undergoing coronary angioplasty.[J].1988,116.
- [3]K.Peter Rentrop,Frederick Feit,Warren Sherman,etc.Late thrombolytic therapy preserves left ventricular function in patients with collateralized total coronary occlusion: Primary end point findings of the second mount sinai-new york university reperfusion trial[J].1989,14(1).
- [4]Wei K.Detection and quantification of coronary stenosis severity with myocardial contrast echocardiography.[J].2001,44(2).
- [5]L, Galiuto,S, Iliceto.Myocardial contrast echocardiography in the evaluation of viable myocardium after acute myocardial infarction.[J].1998,81.
- [6]谢志泉,刘伊丽,查道刚,等.间歇二次谐波全氟显超声造影评价心肌缺血与坏死的价值[J].2000,(1).