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The variation of protein C anticoagulant activity in patients with maintenance hemodialysis treatment
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1671-0282.2003.02.003
- Key Word:
- 尿毒症;血液透析;抗凝血因子
Abstract： 目的探讨血浆抗凝血因子PC,PS,TM在尿毒症止血、凝血异常导致出血并发症中的作用.方法采用双抗夹心ELISA法,发色底物法测定45例尿毒症血透患者血浆PC(PCAg,APC),PS(TPS,FPS),TM含量.结果尿毒症患者PCAg,TPS,FPS,TM含量明显高于正常对照组(P＜0.05,P＜0.001),而PC活性(APC)明显低于对照组(P＜0.001).维持性血透患者血浆APC,TPS,FPS血透后明显升高(P＜0.05,P＜0.001);TM血透后明显降低(P＜0.001).有出血倾向的尿毒症患者血浆APC均明显升高(P＜0.05).结论尿毒症患者蛋白C抗凝活性降低(APC),与尿毒症时高凝倾向和血栓形成有关.血液透析治疗的尿毒症患者在原有高凝状态基础上,透析后仍可激活凝血系统,使体内蛋白C抗凝途径的抗凝活性增强.
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