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Effects of helium-oxygen mixture in mechanically ventilated patients with severe chronic obstructive pulmonary disease
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1671-0282.2003.01.004
- Key Word:
- 呼吸衰竭;机械通气;氦-氧混合气;慢性阻塞性肺病
Abstract： 目的探讨吸入氦-氧混合气对重症慢性阻塞性肺病(COPD)机械通气患者的治疗作用以及对机械通气患者脱机的作用.方法选择12例重症COPD机械通气患者随机分为氦-氧混合气组(70%氦;30%氧)和对照组(FiO2:30%),观察治疗前、治疗后30、90min、6h的呼吸力学指标(气道峰压、平台压、吸气阻力、呼气阻力)以及内源性呼气末正压的变化;选择准备脱机的机械通气患者6例,按自身对照方式脱机后随机先后吸入氦-氧混合气(70%氦-30%氧)或低浓度氧(FiO2:30%)观察治疗前、治疗后30、90min、6h和停止治疗后30 min(重新上机进行压力支持通气)的动脉血气指标.结果机械通气患者应用氦氧混合气治疗后气道压力、气道阻力和内源性呼气末正压均有明显下降,与对照组比较差异有显著性意义;脱机患者吸入氦-氧混合气后与对照组比较pH、PaO2、PaCO2差异均具有显著性意义.结论吸入氦-氧混合气在治疗重症COPD机械通气患者方面能够明显降低气道压力和气道阻力,避免气压伤的发生;应用氦氧混合气可以有效避免脱机患者血气指标的恶化,可能有助于患者的顺利脱机.
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